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Alovudine

Name: Alovudine
Brand: TargetMol
SKU: T4683
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4683Cas No. 25526-93-6

Alias 3'-Deoxy-3'-fluorothymidine

Alovudine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and is a better biomarker in pancreatic cancer.

Alovudine

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Purity: 99.41%

Catalog No. T4683Alias 3'-Deoxy-3'-fluorothymidineCas No. 25526-93-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$33	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$101	In Stock	In Stock
100 mg	$134	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.41%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Alovudine AI Summary

Alovudine exhibits significant antiviral activity primarily against HIV-1, showing potent bioactivity with various effective dose (ED50) values, such as 0.001 µM in MT-4 cells and 1.0 nM in other assays. It demonstrates a high selectivity index (SI) of 197.0, reflecting its selectivity in targeting HIV-1 infected cells over normal uninfected cells. Additionally, Alovudine inhibits HIV reverse transcriptase with an IC50 of less than 50.0 nM and shows low cytotoxicity, with a CD50 of 0.197 µM in MT-4 cells. Beyond HIV-1, Alovudine also inhibits thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis with a Ki value of 28000.0 nM and exhibits modest antiretroviral activity against HIV-2 strains. It shows variable activity against other viruses, including weak inhibition against SARS-CoV-2, and specific activity against Human adenovirus 2 with an EC50 of 1200.0 nM. Furthermore, it demonstrates inhibitory effects on tyrosyl-DNA phosphodiesterase 1 and shows mild hepatotoxicity in preclinical studies. Other observed bioactivities include its role as a potential inhibitor in various enzymatic and biological assays, reflecting its broad-spectrum antiviral potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Alovudine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and is a better biomarker in pancreatic cancer.
Synonyms	3'-Deoxy-3'-fluorothymidine

Chemical Properties

Molecular Weight	244.22
Formula	C₁₀H₁₃FN₂O₄
Cas No.	25526-93-6
Smiles	Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O
Relative Density.	1.44 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (225.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (10.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0947 mL	20.4733 mL	40.9467 mL	204.7334 mL
5 mM	0.8189 mL	4.0947 mL	8.1893 mL	40.9467 mL
10 mM	0.4095 mL	2.0473 mL	4.0947 mL	20.4733 mL
20 mM	0.2047 mL	1.0237 mL	2.0473 mL	10.2367 mL
50 mM	0.0819 mL	0.4095 mL	0.8189 mL	4.0947 mL
100 mM	0.0409 mL	0.2047 mL	0.4095 mL	2.0473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc