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1,2,3,6-Tetragalloylglucose

Name: 1,2,3,6-Tetragalloylglucose
Brand: TargetMol
SKU: TN1160
Price: 169 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1160Cas No. 79886-50-3

Alias TeGG, 1,2,3,6-Tetra-O-galloyl-β-D-glucose

1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).

1,2,3,6-Tetragalloylglucose

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Purity: 99.52%

Catalog No. TN1160Alias TeGG, 1,2,3,6-Tetra-O-galloyl-β-D-glucoseCas No. 79886-50-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$169	In Stock	In Stock
5 mg	$428	-	In Stock
10 mg	$662	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,370	-	In Stock
1 mL x 10 mM (in DMSO)	$628	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).
Targets&IC50	UGT1A1:1.68 μM(Ki), Anticomplement activity:34 microM
In vitro	Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-Tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 1,2,3,6-Tetragalloylglucose exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(+)), and superoxide radicals (O(2)(-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation[1]
Synonyms	TeGG, 1,2,3,6-Tetra-O-galloyl-β-D-glucose

Chemical Properties

Molecular Weight	788.57
Formula	C₃₄H₂₈O₂₂
Cas No.	79886-50-3
Smiles	O[C@@H]1[C@@H](COC(=O)c2cc(O)c(O)c(O)c2)O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Relative Density.	2.02 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,The compound is unstable in solution. Please use soon,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (115.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2681 mL	6.3406 mL	12.6812 mL	63.4059 mL
5 mM	0.2536 mL	1.2681 mL	2.5362 mL	12.6812 mL
10 mM	0.1268 mL	0.6341 mL	1.2681 mL	6.3406 mL
20 mM	0.0634 mL	0.3170 mL	0.6341 mL	3.1703 mL
50 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2681 mL
100 mM	0.0127 mL	0.0634 mL	0.1268 mL	0.6341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc