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1,2,3,6-Tetragalloylglucose

Catalog No. TN1160 CAS 79886-50-3

Synonyms: 1,2,3,6-Tetra-O-galloyl-β-D-glucose, 1,2,3,6-四-O-没食子酰-Β-D-葡萄糖, TeGG

1,2,3,6-Tetragalloylglucose has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).

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1,2,3,6-Tetragalloylglucose, CAS 79886-50-3

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	1,2,3,6-Tetragalloylglucose has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).
Targets&IC50	UGT1A1:1.68 μM(Ki), anticomplement activity:34 microM
In vitro	Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-Tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 1,2,3,6-Tetragalloylglucose exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(+)), and superoxide radicals (O(2)(-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation[1]

Synonyms	1,2,3,6-Tetra-O-galloyl-β-D-glucose, 1,2,3,6-四-O-没食子酰-Β-D-葡萄糖, TeGG
Molecular Weight	788.57
Formula	C34H28O22
CAS No.	79886-50-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL (115.40 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63. 2. Park JB, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018 Oct;120:651-661.

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Keywords

1,2,3,6-Tetragalloylglucose 79886-50-3 代谢 LDL UGT Inhibitor TeGG 1,2,3,6Tetragalloylglucose inhibit 1,2,3,6 Tetragalloylglucose 1,2,3,6-Tetra-O-galloyl-β-D-glucose inhibitor

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