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(-)-Anonaine

Catalog No. TN1393 CAS 1862-41-5

(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.

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(-)-Anonaine, CAS 1862-41-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 340.00
5 mg	In stock	$ 812.00
10 mg	In stock	$ 1,090.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00
1 mL * 10 mM (in DMSO)	In stock	$ 970.00

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Purity: 99.60%

ee: 99.66%

Purity: 99.22%

ee: 99.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.
Targets&IC50	HepG2 cells:38.3 ± 2.3 μg/ml(CC50), HepG2 cells:23.2 ± 2.7 μg/ml
In vitro	(-)-Anonaine (50-200 μM ; 24h ; ) exhibited significant inhibition to cell growth and migration activities on human lung cancer H1299 cells.[1] (-)-Anonaine (10-200 μM) significant nuclear damages of H1299 cells were observed treatment in a comet assay, whereas higher concentrations (6 and 30 mM) of (-)-anonaine concentrations were required to cause DNA damages in an in vitro plasmid cleavage assay.[1]

Molecular Weight	265.31
Formula	C17H15NO2
CAS No.	1862-41-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.65 mg/mL (10 mM)

References and Literature

1. Chen BH,et al. (-)-Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. J Agric Food Chem. 2011 ; 59(6):2284-2290. 2. Chen CY, et al. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol. 2008 ; 46(8):2694-2702. 3. Lee JJ, et al. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Molecules. 2008 ; 13(2):475-487. 4. Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269. 5. Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Anti-Parasitic Compound Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Bioactive Compounds Library Max Anti-infective Natural Product Library Anti-Tumor Natural Product Library Antioxidant Compound Library

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Keywords

(-)-Anonaine 1862-41-5 Apoptosis Microbiology/Virology oxidation-reduction Antioxidant Parasite Antifungal ( ) Anonaine ()Anonaine Anonaine inhibitor inhibit

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