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β-Amyloid (1-42), human

Catalog No. TP1007 CAS 107761-42-2

Synonyms: β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) human

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

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β-Amyloid (1-42), human Chemical Structure

β-Amyloid (1-42), human, CAS 107761-42-2

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100 μg	4-5 weeks	$ 468.00

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Purity: 99.52%

Biological Description

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Description

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

In vitro

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].

Synonyms	β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) human
Molecular Weight	4514.04
Formula	C203H311N55O60S
CAS No.	107761-42-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (11.08 mM), Sonication is recommended.

References and Literature

1. Solntseva EI, et al. Impact of amyloid-β peptide (1-42) on voltage-gated ion currents in molluscan neurons. Bull Exp Biol Med. 2011 Oct;151(6):671-4.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Anti-Alzheimer's Disease Compound Library Anti-Neurodegenerative Disease Compound Library

Related Products

Related compounds with same targets

β-Amyloid (31-35) BSBM7 CGP52411 ALZ-801 Tolcapone Silybin B Astrophloxine LY 2389575 hydrochloride

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Keywords

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