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(S)-3,4-DCPG HCl

Catalog No. T23288L CAS T23288L

Synonyms: (S)-3,4-Dicarboxyphenylglycine HCl, (S)-3,4-DCPG HCl(201730-11-2 Free base)

(S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM.

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(S)-3,4-DCPG HCl, CAS T23288L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 193.00
5 mg	In stock	$ 486.00
10 mg	In stock	$ 695.00
25 mg	In stock	$ 1,090.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,970.00
500 mg	In stock	$ 3,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 437.00

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Purity: 99.90%

Purity: 99.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM.
Targets&IC50	mGluR8a (human):31 nM (EC50)
In vivo	(S)-3,4-DCPG (3-100 mg/kg, i.p.) maked c-Fos as an indicator of neuronal activity in specific brain regions 2 hours after systemic administration. In wild-type mice, (S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus.[2]

Synonyms	(S)-3,4-Dicarboxyphenylglycine HCl, (S)-3,4-DCPG HCl(201730-11-2 Free base)
Molecular Weight	275.64
Formula	C10H10ClNO6
CAS No.	T23288L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (36.28 mM)

References and Literature

1. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 ; 40(3):311-318. 2. Linden AM, et al. Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology. 2003 ; 45(4):473-483. 3. Jiang FL, et al. Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. Epilepsia. 2007 ; 48(4):783-792. 4. Marabese I, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 ; 52(2):253-262. 5. Stachowicz K, et al. Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats. Pharmacol Rep. 2005 ; 57(6):856-860. 6. Johnson KA, et al. The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease. Neuropharmacology. 2013 ; 66:187-195.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library

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Keywords

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