Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
TN1140	Onjisaponin B	35906-36-6	99.88%
TN1140	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...
T10990	Dehydrocorydaline chloride	10605-03-5	99.88%
T10990	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
T0320	Colchicine	64-86-8	99.88%
T0320	Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to micro...
T1215	Nicardipine hydrochloride	54527-84-3	99.87%
T1215	Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium ...
T1178	Temozolomide	85622-93-1	99.87%
T1178	Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic acti...
T1792	Regorafenib	755037-03-7	99.87%
T1792	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
T3001	Honokiol	35354-74-6	99.87%
T3001	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T5842	Bromocriptine mesylate	22260-51-1	99.87%
T5842	Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)
TL0004	FERULIC ACID METHYL ESTER	2309-07-1	99.87%
TL0004	FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This nat...
T1764	Adezmapimod	152121-47-6	99.87%
T1764	Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autoph...
T2146	Fulvestrant	129453-61-8	99.87%
T2146	Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell prolif...
T2144	Tacrolimus	104987-11-3	99.87%
T2144	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosp...
T1050	Prazosin hydrochloride	19237-84-4	99.87%
T1050	Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
T3068	AT9283	896466-04-9	99.87%
T3068	AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
T0334	Rosiglitazone	122320-73-4	99.87%
T0334	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidi...
T0462	Cilostazol	73963-72-1	99.87%
T0462	Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
T0951	Hydroxychloroquine sulfate	747-36-4	99.87%
T0951	Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malari...
T6641	Rilmenidine Phosphate	85409-38-7	99.87%
T6641	Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T0987	Gimeracil	103766-25-2	99.86%
T0987	Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
TQ0064	Peretinoin	81485-25-8	99.86%
TQ0064	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.