Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T6858	Hydroxyprogesterone caproate	630-56-8	99.78%
T6858	Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system...
T2338	JZL195	1210004-12-8	99.78%
T2338	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T6340	Enalaprilat Dihydrate	84680-54-6	99.78%
T6340	Enalaprilat Dihydrate (MK-422 Dihydrate) （IC50=1.94 nM） is a potent angiotensin-converting enzyme (ACE) inhibitor.
T15806	LY2562175	1103500-20-4	99.78%
T15806	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T1339	5-Azacytidine	320-67-2	99.78%
T1339	5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing ...
T1670	Lanatoside C	17575-22-3	99.78%
T1670	Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular h...
T9169	MPP+ iodide	36913-39-0	99.78%
T9169	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in s...
T2500	Cediranib	288383-20-0	99.78%
T2500	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (I...
T2993	Cordycepin	73-03-0	99.78%
T2993	Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic ac...
T1076	Dexamethasone	50-02-2	99.77%
T1076	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T0913	Sulfamerazine	127-79-7	99.77%
T0913	Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
T2503	PAC-1	315183-21-2	99.77%
T2503	PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers,...
T0769	Aceglutamide	2490-97-3	99.77%
T0769	Aceglutamide (N2-Acetylglutamine) is an acetyl derivative of the amino acid L-glutamine, used to improve memory.
T1634	Glibenclamide	10238-21-8	99.77%
T1634	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T8055	TFEB activator 1	39777-61-2	99.77%
T8055	TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's dise...
T7530	PD146176	4079-26-9	99.77%
T7530	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses...
T8526	Metformin	657-24-9	99.77%
T8526	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensit...
T1662	5-Aminolevulinic acid hydrochloride	5451-09-2	99.77%
T1662	5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.
T2454	Dacinostat	404951-53-7	99.77%
T2454	LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
T0589	Xylitol	87-99-0	99.76%
T0589	Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sw...