Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T1601	Lomustine	13010-47-4	99.86%
T1601	Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T0400	Nitroxoline	4008-48-4	99.86%
T0400	Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinar...
T5725	Salvianolic acid B	121521-90-2	99.86%
T5725	Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregatio...
T2697	KN-93	139298-40-1	99.86%
T2697	KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
T6213	Vinorelbine ditartrate	125317-39-7	99.86%
T6213	Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6407	β-Lapachone	4707-32-8	99.86%
T6407	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T0767	Sulfapyridine	144-83-2	99.85%
T0767	Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
T21627	Hoechst 33342 trihydrochloride	875756-97-1	99.85%
T21627	Hoechst 33342 trihydrochloride (bisBenzimide H 33342 trihydrochloride;HOE 33342 trihydrochloride) is a membrane permeant DNA stain with blue fluorescence.
T3814	Isorhapontigenin	32507-66-7	99.85%
T3814	Isorhapontigenin (Isorhapotogenin) is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is f...
T2170	SKF-96365 hydrochloride	130495-35-1	99.85%
T2170	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells...
T6069	Gemcitabine hydrochloride	122111-03-9	99.85%
T6069	Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor an...
T6473	Dioscin	19057-60-4	99.85%
T6473	Dioscin (Collettiside III) is a saponin with antitumor activities.
T6230	Imatinib	152459-95-5	99.85%
T6230	Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with...
T0885	Sulfamethoxazole	723-46-6	99.85%
T0885	Sulfamethoxazole (STX 608) is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classi...
T6837	Flavopiridol	146426-40-6	99.85%
T6837	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective fo...
T11372	GC7 Sulfate	150417-90-6	99.85%
T11372	GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so ...
T3078	SGI-1776	1025065-69-3	99.84%
T3078	SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.
T0853	Adenosine	58-61-7	99.84%
T0853	Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T0152	Bosutinib	380843-75-4	99.84%
T0152	Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.
T7044	Norepinephrine	51-41-2	99.84%
T7044	Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression ...