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Sulfamethoxazole

Name: Sulfamethoxazole
Brand: TargetMol
SKU: T0885
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0885Cas No. 723-46-6

Alias STX 608, Ro 4-2130

Sulfamethoxazole (STX 608) is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification of sulfamethoxazole is Sulfonamides.

Sulfamethoxazole

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Purity: 99.92%

Catalog No. T0885Alias STX 608, Ro 4-2130Cas No. 723-46-6

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$46	In Stock	In Stock
100 mg	$58	In Stock	In Stock
200 mg	$70	In Stock	In Stock
500 mg	$90	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Sulfamethoxazole AI Summary

Sulfamethoxazole exhibits a broad spectrum of bioactivities including antimicrobial, antiviral, and enzyme inhibition properties. This compound demonstrates potent antibacterial activity against various bacterial strains such as Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa with Minimum Inhibitory Concentration (MIC) values ranging from 1.0 to 256.0 µg/mL. It also shows potential in treating Candida albicans infections in immunosuppressed mice, evidenced by reduced tissue colony formation units (cfu) in the brain and kidney. Additionally, Sulfamethoxazole inhibits key enzymes such as dihydrofolate reductase in Pneumocystis carinii and dihydropteroate synthase in Escherichia coli, with IC50 values of 100.0 nM and 4700.0 nM, respectively. Its antiviral activity includes inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, showing moderate potency with IC50 values around 10 µM. Pharmacokinetic properties of Sulfamethoxazole are notable, with high oral bioavailability (F ≥ 80%) and a volume of distribution of 0.3 L.kg-1. It also exhibits different plasma protein binding affinities in human (57%) and CD-1 mouse plasma (9%). Moreover, Sulfamethoxazole acts as an inhibitor for human immunodeficiency virus type 1 protease (Kd = 577.0 nM, Ki = 10.1 nM) and shows time-dependent inhibition of several human CYP enzymes, implicating its interaction with drug metabolism pathways. However, there is some evidence of potential drug-induced liver injury (DILI) based on various liver toxicity assays. In conclusion, Sulfamethoxazole presents itself as a versatile compound with significant antimicrobial and antiviral activities, as well as inhibitory effects on enzymatic functions, making it a potential candidate for further therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfamethoxazole (STX 608) is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification of sulfamethoxazole is Sulfonamides.
Synonyms	STX 608, Ro 4-2130

Chemical Properties

Molecular Weight	253.28
Formula	C₁₀H₁₁N₃O₃S
Cas No.	723-46-6
Smiles	CC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
Relative Density.	1.462 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (1006.79 mM), Sonication is recommended.

Ethanol: 22 mg/mL (86.86 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9482 mL	19.7410 mL	39.4820 mL	197.4100 mL
5 mM	0.7896 mL	3.9482 mL	7.8964 mL	39.4820 mL
10 mM	0.3948 mL	1.9741 mL	3.9482 mL	19.7410 mL
20 mM	0.1974 mL	0.9870 mL	1.9741 mL	9.8705 mL
50 mM	0.0790 mL	0.3948 mL	0.7896 mL	3.9482 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0395 mL	0.1974 mL	0.3948 mL	1.9741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc