tumor-infiltrating — TargetMol Chemicals

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Search Results for " tumor-infiltrating "

Compounds

Cat No.	Product Name	Synonyms	Targets
T7776	ADH-503	GB1275	Complement System
	ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.		Complement System
T13379	(Z)-Leukadherin-1	ADH-503 free base	Complement System
	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.		Complement System
T26699	AZ10397767	AZ 10397767,AZ-10397767
	AZ10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). AZ10397767 significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models.
T79528	SWS1		PD-1/PD-L1
	SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating anti-tumor efficacy, as evidenced by a 66.1% tumor growth inhibi...		PD-1/PD-L1
T76410	Tyrosinase (206-214), human
	Tyrosinase (206-214), human (AFLPWHRLF), is a 9-amino acid peptide and an epitope of tyrosinase that can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL) [1].
T71890	F5446
	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby ...
T77090	Mitazalimab
	Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that exhibits directed activity against tumors. By activating antigen-presenting cells, such as dendritic cells (DC), it triggers the initiation of t...
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vi...
T78053	PD-L1-IN-2		PD-1/PD-L1
	PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell...		PD-1/PD-L1