nachr antagonist 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61064	nAChR antagonist 1		Others
	nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzh...		Others
T14333	Asoxime dichloride	Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate,Asoxime (dichloride),HI-6	AChR
	Asoxime dichloride (Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antig...		AChR
T37094	(S)-UFR2709 hydrochloride	(S)-UFR2709 hydrochloride	Others
	(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol pre...		Others
T60819	Flupyrimin		Others
	Flupyrimin is the insect nicotinic acetylcholine receptor (nAChR) antagonist [1].		Others
T60588	T761-0184		Others
	T761-0184 is a potent antagonist of α7 nicotinic receptor (nAChR) [1].		Others
T80190	Waglerin-1
	Waglerin-1, a competitive antagonist of the muscle nicotinic acetylcholine receptor (nAChR), comprises 22 amino acids [1].
T80480	αA-Conotoxin OIVA	αA-OIVA
	αA-Conotoxin OIVA (αA-OIVA), a peptide derived from conotoxin, serves as a selective nAChR antagonist and exhibits potent activity with an IC50 of 56 nM against mammalian fetal muscle nAChR, leading to muscle paralysis [...
T75876	α-Conotoxin PIA TFA
	α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist. This compound shows promise for research into Parkinson’s disease and schizophrenia [1].
T75877	α-Conotoxin AuIB TFA
	α-Conotoxin AuIB TFA, a potent selective antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), effectively inhibits nAChRs expressed in Xenopus oocytes, demonstrating an inhibitory concentration (IC 50) of 0.7...
T76343	α-Conotoxin S IA
	α-Conotoxin SIA is a selective antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting high affinity specifically for the muscle subtype. It preferentially binds to the α/δ interface in mouse muscle nAChR....
T80476	α-Conotoxin RgIA	α-RgIA
	α-Conotoxin RgIA (α-RgIA), a specific α9α10 nAChR antagonist, is derived from the venom of Conus regius and has applications in researching neurological diseases [1].
T80219	α-Conotoxin TxID
	α-Conotoxin TxID is a potent antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting an inhibitory half-maximal inhibitory concentration (IC50) of 12.5 nM. Its inhibitory activity against the closely ...
T80167	αC-Conotoxin PrXA	αC-PrXA
	αC-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult α1β1εδ subtype and 3....
T75875	α-Conotoxin PnIA TFA
	α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, holds promise for neurological research, particularly in studying neuropathic pain and Alzheimer's disease [1].
T80479	αO-Conotoxin GeXIVA
	αO-Conotoxin GeXIVA, a potent antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR), exhibits an inhibition concentration 50 (IC50) of 12 nM against rat α9α10 nAChRs. This compound has demonstrated analgesic p...
T78827	CVN417		Others
	CVN417 is an orally active antagonist of nAChR containing the α6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion. It inhibits Ca(2+) efflux through nAChR subunits, displaying IC5...		Others
T75778	COG 133 TFA		Others
	COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a ...		Others
T80166	α-Conotoxin BuIA
	α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α...
T80466	κ-Bungarotoxin	κ-Bgt
	κ-Bungarotoxin (κ-Bgt) is a selective and potent antagonist of α3β2 neuronal nicotinic acetylcholine receptors, exhibiting slow reversibility and an IC50 of 2.30 nM [1].
T83662	2,3-dinor-8-iso Prostaglandin F1α	2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP	Others
	2,3-Dinor-8-iso Prostaglandin F1α (2,3-dinor-8-iso PGF1α), an isoprostane and active metabolite of arachidonic acid deriving its formation from non-enzymatic free radical peroxidation, acts as an active metabolite of the...		Others