mglur5 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6457	CTEP	mGluR5 inhibitor,RO 4956371	GluR
	CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.		GluR
T38659	mGluR5 modulator 1
	mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment...
T81801	mGluR5 antagonist-1
	mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].
T22641	CDPPB		GluR
	CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).		GluR
T23514	VU-1545	VU 1545	GluR
	VU-1545 is mGlu5 positive allosteric modulator.		GluR
T2053	ADX-47273	BA 94673139	GluR
	ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).		GluR
T11393	GET73	Gamma hydroxybutyric acid analogue,GET 73	GluR
	GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.		GluR
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T14389	AZD 9272		GluR
	AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.		GluR
T10573	BMT-145027		GluR
	BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).		GluR
T8457	NPS2390		GluR
	NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)		GluR
T26520	ABP688	ABP-688,ABP 688	GluR
	ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.		GluR
T22976	MFZ 10-7		Others , GluR
	MFZ 10-7 is anegative allosteric modulator of the mGluR5.		Others , GluR
T22736	DMeOB	3,3'-Dimethoxybenzaldazine	GluR
	DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.		GluR
T15275	Fenobam		GluR
	Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric mo...		GluR
T10809L	CHPG hydrochloride	CHPG hydrochloride(170846-74-9 Free base)	ERK , NF-κB , GluR
	CHPG hydrochloride is a selective agonist of mGluR5.		ERK , NF-κB , GluR
T23353	(E/Z)-SIB-1893	SIB 1893	Others , GluR
	(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .		Others , GluR
T23509	VU 0285683		GluR
	VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.		GluR
T23515	VU-29	VU 29	GluR
	VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).		GluR
T22711	DCB	3,3'-dichlorobenzaldazine	Others , GluR
	DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of ...		Others , GluR