9
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21995 | XAP044 | GluR | |
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1]. | |||
T13321 | VU6005649 | GluR | |
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). | |||
T13323 | VU6012962 | GluR | |
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM). | |||
T6726 | VU0361737 | ML-128,VU 0361737 | GluR |
VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity... | |||
T15692 | L-AP4 | L-APB,L-AP 4 | GluR |
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively). | |||
T23008 | MMPIP | MMPIP hydrochloride | Others |
allosteric mGlu7-selective receptor antagonist | |||
T35082 | VU6010608 | VU-6010608,VU 6010608 | |
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
T21935 | AMN082 | AMN 082 dihydrochloride | GluR |
AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. | |||
T37127 | L-AP4 monohydrate | L-AP4 monohydrate | |
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhe... |