Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 249.00 | |
50 mg | In stock | $ 448.00 | |
100 mg | In stock | $ 658.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM). |
Targets&IC50 | mGlu7:347 nM |
In vitro | Compared to the other seven mGlu receptor subtypes, VU6012962 is highly selective for mGlu7. |
In vivo | In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety . |
Molecular Weight | 448.4 |
Formula | C21H19F3N4O4 |
CAS No. | 2313526-86-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (278.77 mM), sonification is recommended.
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VU6012962 2313526-86-0 Neuroscience GluR VU 6012962 Inhibitor Metabotropic glutamate receptors inhibit mGluR VU-6012962 inhibitor