Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 515.00 | |
100 mg | In stock | $ 777.00 | |
500 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). |
Targets&IC50 | mGlu8 receptor: 2.6 μM , mGlu7 receptor:(EC50)0.65 μM |
In vitro | VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor(EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50. |
In vivo | In wild-type mice VU6005649 shows modest but significant pro-cognitive effects on associative learning and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model. |
Molecular Weight | 357.28 |
Formula | C16H12F5N3O |
CAS No. | 2137047-43-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (167.94 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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VU6005649 2137047-43-7 Neuroscience GluR VU-6005649 Inhibitor inhibit VU 6005649 mGluR Metabotropic glutamate receptors inhibitor