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Search Results for " acidification "

10

Compounds

Cat No. Product Name Synonyms Targets
T23004 ML-SA1 Mucolipin synthetic agonist 1 Others , TRP/TRPV Channel
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV...
T38089 2F-Peracetyl-Fucose 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos Others
2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) is a potent fucosyltransferase (FUT) inhibitor that inhibits salivary acidification and fucosylation in an in vitro inflammatory model.
T11191 EN6 Proton pump , Autophagy
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...
T69550 NS-3736
NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.
T72003 SKF-104557
N-Despropyl ropinirole is an active metabolite of the dopamine D2 receptor agonist ropinirole. It increases extracellular acidification rates in CHO cells expressing human dopamine D2, D3, and D4 receptors (EC50s = 0.63,...
T36116 Concanamycin B
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late...
T37547 Trans-Urocanic Acid
trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes ...
T80516 Human GALP (3-32) Galanin-like peptide (3-32) Neuropeptide Y Receptor
Human GALP (3-32) (Galanin-like peptide (3-32)) serves as a high-affinity agonist for galanin receptors GalR1 (IC50 = 33 nM) and GalR2 (IC50 = 15 nM), as evidenced by competitive binding studies. It demonstrates signific...
T76042 Angiopeptin TFA
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, acts as a partial agonist at sst 2/sst 5 receptors, exhibiting IC50 values of 0.26 nM and 6.92 nM, respectively. This compound effectively inhibits the rele...
T83889 C-02
C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a co...
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