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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T17189 | U-46619 | 9,11-Methanoepoxy PGH2 | Progesterone Receptor , PPAR |
U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. | |||
TN6975 | Cirsiumaldehyde | 5,5’-oxydimethylenebis(2-furfural) | Platelet aggregation |
Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM)... | |||
T6594 | MNS | Syk , Src , p97 | |
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | |||
TN5569 | 2-Deacetoxytaxinine B | ||
2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation. | |||
T72591 | Sp-5,6-DCl-cBIMPS | ||
Sp-5,6-DCl-cBIMPS is a potent, specific activator of cAMP-dependent protein kinases (cAMP-PK) that enhances insulin release and inhibits U46619-induced activation of Rho, Gq, and G12/G13 in platelets. | |||
T36150 | 14,15-EE-5(Z)-E | ||
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.... | |||
T35506 | (±)12-HEPE | ||
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly t... | |||
T36550 | CAY10535 | ||
TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucida... | |||
T36717 | RWJ-56110 dihydrochloride | ||
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits... |