Powder: -20°C for 3 years | In solvent: -80°C for 2 years
MNS is a Tyrosine Kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 45.00 | |
200 mg | In stock | $ 72.00 | |
500 mg | In stock | $ 146.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. |
Targets&IC50 | p97:1.7 μM, Syk:2.5 μM, Src:29.3 μM |
In vitro | LY3023414 shows high solubility across a wide pH range. In vitro, inhibition of PI3K/AKT/mTOR signaling by LY3023414 causes G1 cell-cycle arrest and resulted in broad antiproliferative activity in cancer cell panel screens. In cell-based assays, LY3023414 inhibition of PI3K and mTOR is assessed in the PTEN-deficient U87 MG glioblastoma cell line. LY3023414 inhibits the phosphorylation of AKT at position T308 downstream of PI3K at an IC50 of 106 nM. Similarly, LY3023414 inhibits phosphorylation of AKT at position S473 (IC50 = 94.2 nM) by mTORC2 as well as phosphorylation of mTORC1 kinase targets p70S6K (position T389; IC50 =10.6 nM) and 4E-BP1 (positions T37/46; IC50 = 187 nM). The downstream phosphorylation of S6RP at positions pS240/244 (IC50 = 19.1 nM) by p70S6K was inhibited as well, indicating target inhibition along the entire PI3K/AKT/mTOR pathway by LY3023414[1]. |
Molecular Weight | 193.16 |
Formula | C9H7NO4 |
CAS No. | 1485-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 19.3 mg/mL (100 mM)
Ethanol: 1 mg/mL (5 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MNS 1485-00-3 Angiogenesis Tyrosine Kinase/Adaptors Ubiquitination Syk Src p97 thrombin aggregation NSC170724 Inhibitor NSC 170724 activation inhibit NSC-170724 Spleen tyrosine kinase derivative GPIIb/IIIa beta-nitrostyrene platelet inhibitor