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MNS

Catalog No. T6594   CAS 1485-00-3

MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

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MNS, CAS 1485-00-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
Targets&IC50 p97:1.7 μM, Syk:2.5 μM, Src:29.3 μM
In vitro LY3023414 shows high solubility across a wide pH range. In vitro, inhibition of PI3K/AKT/mTOR signaling by LY3023414 causes G1 cell-cycle arrest and resulted in broad antiproliferative activity in cancer cell panel screens. In cell-based assays, LY3023414 inhibition of PI3K and mTOR is assessed in the PTEN-deficient U87 MG glioblastoma cell line. LY3023414 inhibits the phosphorylation of AKT at position T308 downstream of PI3K at an IC50 of 106 nM. Similarly, LY3023414 inhibits phosphorylation of AKT at position S473 (IC50 = 94.2 nM) by mTORC2 as well as phosphorylation of mTORC1 kinase targets p70S6K (position T389; IC50 =10.6 nM) and 4E-BP1 (positions T37/46; IC50 = 187 nM). The downstream phosphorylation of S6RP at positions pS240/244 (IC50 = 19.1 nM) by p70S6K was inhibited as well, indicating target inhibition along the entire PI3K/AKT/mTOR pathway by LY3023414[1].
Molecular Weight 193.158
Formula C9H7NO4
CAS No. 1485-00-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 19.3 mg/mL (100 mM)

Ethanol: 1 mg/mL (5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang WY, et al. Mol Pharmacol, 2006, 70(4), 1380-1389. 2. Chou TF, et al. J Biol Chem, 2011, 286(19), 16546-16554.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Kinase Inhibitor Library Ubiquitination Compound Library Angiogenesis related Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

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Keywords

MNS 1485-00-3 蛋白酪氨酸激酶 泛素化 血管生成 Syk Src p97 thrombin aggregation NSC170724 Inhibitor NSC 170724 activation inhibit NSC-170724 Spleen tyrosine kinase derivative GPIIb/IIIa beta-nitrostyrene platelet inhibitor