Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 µM, respectively. [1] These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8.8 µM).[2]
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 293.00 | |
50 μg | 35 days | $ 555.00 | |
100 μg | 35 days | $ 987.00 | |
250 μg | 35 days | $ 2,300.00 |
Description | (±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 µM, respectively. [1] These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8.8 µM).[2] |
Molecular Weight | 318.457 |
Formula | C20H30O3 |
CAS No. | 81187-21-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(±)12-HEPE 81187-21-5 12-HEPE (±)12 HEPE (±)12HEPE inhibitor inhibit