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Search Results for " u251 "

11

Compounds

Cat No. Product Name Synonyms Targets
T5784 Topotecan NSC 609669,SKF 104864A Topoisomerase , Autophagy
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
T5858 Sertindole Lu 23-174 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T32567 Lanuginosine Oxoxylopin,NSC-137553,Oxoxylopine,NSC137553,NSC 137553
Lanuginosine, an aporphine alkaloid, exhibits cytotoxicity against U251.
T83469 10m/ZS44
10m/ZS44, a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor, significantly suppresses tumor growth in mouse xenograft models and induces apoptosis through activation of the SIRT1/p53-mediated pathway, thereby ...
T81967 KY386
KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM. It demonstrates significant anti-cancer activity in DHX33-overexpressing U251-MG cell strain, achieving an IC50 of 20 nM, and exhibits...
T36407 Pyrrolidine Ricinoleamide
Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid. It constitutes about 90% of the fatty acids in castor oil. Pyrrolidine Ricinoleamide is a derivative of the amide of ricinoleic acid that shows potent antip...
T36449 (S)-α-Methylbenzyl Ricinoleamide
(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), ki...
T36406 Pyrrolidine Linoleamide
Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the western diet. Pyrrolidine Linoleamide is a derivative of the amide of linoleic acid that shows potent antiprolifera...
T83741 S7 TFA Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPM...
T35558 KAAD-Cyclopamine
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...
T36241 Arecaidine propargyl ester (hydrobromide)
Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0...
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