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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5784 | Topotecan | NSC 609669,SKF 104864A | Topoisomerase , Autophagy |
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. | |||
T5858 | Sertindole | Lu 23-174 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy |
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) | |||
T32567 | Lanuginosine | Oxoxylopin,NSC-137553,Oxoxylopine,NSC137553,NSC 137553 | |
Lanuginosine, an aporphine alkaloid, exhibits cytotoxicity against U251. | |||
T83469 | 10m/ZS44 | ||
10m/ZS44, a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor, significantly suppresses tumor growth in mouse xenograft models and induces apoptosis through activation of the SIRT1/p53-mediated pathway, thereby ... | |||
T81967 | KY386 | ||
KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM. It demonstrates significant anti-cancer activity in DHX33-overexpressing U251-MG cell strain, achieving an IC50 of 20 nM, and exhibits... | |||
T36407 | Pyrrolidine Ricinoleamide | ||
Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid. It constitutes about 90% of the fatty acids in castor oil. Pyrrolidine Ricinoleamide is a derivative of the amide of ricinoleic acid that shows potent antip... | |||
T36449 | (S)-α-Methylbenzyl Ricinoleamide | ||
(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), ki... | |||
T36406 | Pyrrolidine Linoleamide | ||
Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the western diet. Pyrrolidine Linoleamide is a derivative of the amide of linoleic acid that shows potent antiprolifera... | |||
T83741 | S7 TFA | Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH | |
S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPM... | |||
T35558 | KAAD-Cyclopamine | ||
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc... | |||
T36241 | Arecaidine propargyl ester (hydrobromide) | ||
Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0... |