tyk-2-in-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13237L	Ropsacitinib	Tyk2-IN-8,PF-06826647	Tyrosine Kinases
	Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).		Tyrosine Kinases
T13232	TyK2-IN-2		PDE
	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).		PDE
T13233	Tyk2-IN-3		Tyrosine Kinases
	Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).		Tyrosine Kinases
T13235	Tyk2-IN-7		Others
	Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).		Others
T13237	Tyk2-IN-9		Others
	Tyk2-IN-9 (Compound 26), a selective Tyk-2 inhibitor, exhibits IC50 values of 0.076 nM for TYK2-JH2 and 1.8 nM for JAK1-JH2, respectively. This specificity makes it suitable for research into inflammatory or autoimmune d...		Others
T13234	Tyk2-IN-5		Others
	Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).		Others
T61658	TYK2-IN-11
	TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advanc...