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Search Results for " trk-in-7 "

4

Compounds

Cat No. Product Name Synonyms Targets
T61443 Trk-IN-7
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (...
T3678 Entrectinib RXDX-101,NMS-E628 Trk receptor , ROS , ALK , Autophagy , ROS Kinase
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...
T64070 Pan-Trk-IN-3
Pan-Trk-IN-3 is a potent, broad-spectrum inhibitor of Trk and its drug-resistant mutants, acting on TrkA (IC50: 2 nM), TrkB (IC50: 3 nM), TrkC (IC50: 2 nM), TrkAG595R (IC50: 21 nM), TrkAG667C (IC50: 26 nM), TrkAG667S (IC...
T64296 TIY-7
TIY-7 is a selective, orally active inhibitor of the promyosin receptor kinase (TRK) enzyme. TIY-7 exhibited anti-tumour effects in a mouse xenograft model.
TargetMol