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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5784 | Topotecan | NSC 609669,SKF 104864A | Topoisomerase , Autophagy |
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. | |||
T1174 | Topotecan hydrochloride | SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,Topotecan HCl | Apoptosis , Topoisomerase , Autophagy |
Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer. | |||
T63105 | Topotecan hydrochloride hydrate | ||
Topotecan hydrochloride hydrate is an orally active Topoisomerase I inhibitor with anticancer properties. topotecan hydrochloride hydrate is capable of blocking the cell cycle in G0/G1 and S phases and inducing apoptosis... | |||
T71908 | NU1085 | ||
NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combinati... | |||
T73411 | PV-1019 | NSC 744039 | |
PV-1019 (NSC 744039) is a potent, selective inhibitor of Chk2, displaying an IC50 of 24 nM. It effectively inhibits Topotecan-induced Chk2 autophosphorylation and suppresses IR-induced apoptosis [1]. |