ttx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T34885	Tinyatoxin	TNX,TTN,TTX
	Tinyatoxin is a neurotoxin that works through vanillin receptors on sensory nerves.
T37093	4,9-Anhydrotetrodotoxin	4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX
	4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrate...
T7502L	PF 05089771	PF-05089771,PF05089771	Sodium Channel
	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.		Sodium Channel
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
T80181	MitTx-alpha		Sodium Channel
	MitTx-alpha, a component of the complex MitTx, acts as a powerful and enduring agonist specifically targeting acid-sensing ion channels (ASICs), with a pronounced selectivity for ASIC1 under neutral pH conditions. At low...		Sodium Channel
T81787	MitTx-beta
	MitTx-beta, a peptide isolated from the venom of the Texas coral snake (Micrurus tener tener), forms a complex with MitTx-α to comprise MitTx, which exhibits ASIC1 channel activating activity on capsaicin-sensitive nerve...
T80182	MitTx		Sodium Channel
	MitTx, a complex consisting of MitTx-α and MitTx-β, serves as an ASIC1 channel activator, demonstrating EC50 values of 9.4 nM and 23 nM for the ASIC1a and ASIC1b isoforms, respectively. It exhibits high selectivity for A...		Sodium Channel
T27205	DPI 201-106	DPI-201-106	Sodium Channel
	DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents.		Sodium Channel
T28227	Oe-9000	Oe 9000
	Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-r...
T80428	Jingzhaotoxin-34		Sodium Channel
	Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neurons with an IC50 of approximately 85 nM and exerts negligible inf...		Sodium Channel
T80427	Jingzhaotoxin-II		Sodium Channel
	Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels (VGSC), notably slowing the rapid inactivation of TTX-resi...		Sodium Channel
T80495	MHuwentoxin-IV		Sodium Channel
	mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in dorsal root ganglion neurons with an IC50 value of 54.16 nM. Notably, the i...		Sodium Channel
TP2070	BDS I
	Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal ro...
T80488	µ-Conotoxin SIIIA		Sodium Channel
	μ-Conotoxin SIIIA, a tetrodotoxin (TTX)-resistant sodium channel blocker, is a toxic peptide derived from Conus snail venom. It has applications in researching neurological diseases, including neuropathic pain [1].		Sodium Channel
T80189	Hainantoxin-IV	HNTX-IV	Sodium Channel
	Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for binding to the target. This compound also features an inhibi...		Sodium Channel
T80851	VSTx-3	Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3 is a potassium voltage-gated channel (K_V) blocker, which has also been shown to be a potent tetrodotoxin-sensitive (TTX-sensitive) sodium channel inhibitor, with particular efficacy against NaV1.8 channels, as ev...