Search Result

Search Results for " tlr3 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T12516	Polyinosinic-polycytidylic acid sodium	Poly(I:C) sodium	Apoptosis , Others , TLR
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...		Apoptosis , Others , TLR
T10899	CU-CPT17e		TLR
	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).		TLR
T23171	Polyinosinic-polycytidylic acid	Poly(I:C)	TLR
	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.		TLR
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T26626	AN3485 Hydrochloride
	AN3485 Hydrochloride inhibits TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6.
T74760	Polyinosinic acid
	Polyinosinic acid, a single-stranded homonucleic acid and a Toll-like Receptor 3 (TLR3) agonist, enhances the cellular immune response through TLR3 and TRIF. It holds potential applications in immune regulation [1].
T64279	ODN 21158
	ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.
T27967	M199
	M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
T64278	ODN 2088
	ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.
T74912	ODN 24991
	ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN) derivative of INH-ODN 2088, inhibits Toll-like receptors (TLR) 3, TLR7, and TLR9, thereby attenuating TLR3-, TLR7-, and TLR9-mediated immune responses. T...
T80465	CRAMP (140-173) (mouse)
	CRAMP (140-173) (mouse), the ortholog of the human LL-37 antimicrobial peptide, inhibits LPS-induced responses and does not colocalize with TLR3 in BEAS-2B cells [1].
T78995	Biotin-labeled ODN 2088 sodium
	Biotin-labeled ODN 2088 (sodium) acts as a potent inhibitor of TLR3, TLR7, and TLR9. It is utilized to assess cellular uptake and localization of CpG ODN through a biotin detection system coupled with light microscopy.
T78996	FITC-labeled ODN 2088 sodium
	FITC-labeled ODN 2088 (sodium) serves as a potent inhibitor of TLR3, TLR7, and TLR9, and is utilized to assess CpG ODN cellular uptake and localization utilizing confocal laser-scanning microscopy (excitation 495 nm, emi...
T73674	Poly (I:C):Kanamycin (1:1)
	Poly(I:C):Kanamycin (1:1) is a compound comprising an equal mixture of synthetic double-stranded RNA (dsRNA), specifically Poly(I:C), a Toll-like receptor 3 (TLR3) agonist, and kanamycin, a positively charged (poly-NH3) ...
T74052	Polyinosinic-polycytidylic acid potassium
	Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium), a synthetic double-stranded RNA analog, serves as an agonist for toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RIG...
T37287	Enpatoran hydrochloride
	Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showi...
T74067	Poly (I:C):Kanamycin (1:1) (sodium)
	Poly(I:C):Kanamycin (1:1) sodium is a symmetric complex combining Poly(I:C) sodium, a synthetic double-stranded RNA analog acting as a TLR3 and RIG-I/MDA5 agonist, with Kanamycin, an antibacterial agent effective against...
T83895	NCI 126224	NSC 126224
	NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ...
T35672	SMU127
	SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at conce...

Compounds

Polyinosinic-polycytidylic acid sodium

T12516

Synonym: Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Polyinosinic-polycytidylic acid

CRAMP (140-173) (mouse)

T80465

Synonym:

Target:

Biotin-labeled ODN 2088 sodium

T78995

Synonym:

Target:

FITC-labeled ODN 2088 sodium

T78996

Synonym:

Target:

Poly (I:C):Kanamycin (1:1)

T73674

Synonym:

Target:

Polyinosinic-polycytidylic acid potassium

T74052

Synonym:

Target:

Enpatoran hydrochloride

T37287

Synonym:

Target:

Poly (I:C):Kanamycin (1:1) (sodium)

Cat No.	Product Name	Synonyms	Targets
T75481	Guignardone L
	Guignardone L, a metabolite extracted from the endophytic fungus Guignardia mangiferae, possesses toll-like receptor 3 (TLR3) regulating activity [1].

Natural Products

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00544	TLR3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	TLR3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 78.04 kDa and the accession number is A0A2K5WT39.
TMPY-01396	TLR3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TLR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q99MB1.
TMPK-00406	TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q6PCD4.
TMPY-06410	TLR3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	TLR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 79.38 kDa and the accession number is Q6PCD4.
TMPY-04398	MST1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The t...
TMPH-00812	Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO)	HEV-1	E. coli
	Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Act...
TMPH-01270	TRAIP Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...