shp2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40121	SHP2-D26	SHP2-D26
	SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 proteins. Additionally, the degradation of SHP2 induced by SHP...
T39640	JAB-3068	SHP2-IN-6	Phosphatase
	JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor with anticancer and antitumor activity for the study of breast, lung, and esophageal cancers.		Phosphatase
T40250	SHP2 protein degrader-1	SHP2 protein degrader-1
	SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying dis...
T39641	SHP2-IN-6 hydrochloride	SHP2-IN-6 hydrochloride
	SHP2-IN-6 hydrochloride is a highly potent inhibitor of SHP2 with an IC50 of 25.8 nM.
T39658	RMC-4630	SHP2-IN-7,RMC-4630	Phosphatase
	RMC-4630 (SHP2-IN-7) is an inhibitor of SHP2.		Phosphatase
T12903	SHP2 IN-1		Others
	SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).		Others
T81162	SHP2-IN-20
	SHP2-IN-20 (compound 193), a potent SHP2 inhibitor, exhibits an IC50 of 3 nM, making it suitable for glioblastoma research [1].
T79412	SHP2-IN-16
	SHP2-IN-16 (compound 222) is a potent SHP2 inhibitor exhibiting an IC50 of 1 nM, and is applicable in glioblastoma research [1].
T81163	SHP2-IN-19
	SHP2-IN-19 (compound 183) is a SHP2 inhibitor exhibiting potent activity with an IC50 of 3 nM, and is utilized in glioblastoma research [1].
T78694	SHP2-IN-13
	SHP2-IN-13 is an orally active, highly selective allosteric inhibitor targeting the SHP2 “tunnel site,” exhibiting an IC50 of 83.0 nM. It holds potential for research into cancers with RTK oncogenic drivers and diseases ...
T63993	SHP2 inhibitor LY6
	SHP2 inhibitor LY6 (LY6) is a potent and selective SHP2 inhibitor (IC50: 9.8 μM) that blocks SHP2-mediated cell signaling and proliferation.
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. ...
T78611	SHP2-IN-5
	SHP2-IN-5 (compound 1) is a non-receptor protein tyrosine phosphatase inhibitor targeting SHP2 with an IC50 value of 97 nM, associated with regulating cell growth and proliferation. This compound exhibits potential thera...
T81165	SHP2-IN-17
	SHP2-IN-17 (compound 192) is a potent inhibitor of SHP2, exhibiting an IC50 of 2 nM and holds potential for use in glioblastoma research [1].
T79108	SHP2-IN-14
	SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2, displaying strong anti-tumor activity with an IC50 of 7 nM. It inhibits tumor progression in NCI-H358 tumor-bearing mice and demonstrates ...
T61891	SHP2-IN-8
	SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement（ Δ Tm = 7.01 ℃）。 ...
T81164	SHP2-IN-18
	SHP2-IN-18 (compound 183) is a potent SHP2 inhibitor, exhibiting an IC50 of 3 nM and applicable to glioblastoma research [1].
T81161	SHP2-IN-21
	SHP2-IN-21 (compound 208) is an inhibitor of SHP2, exhibiting an IC50 of 3 nM, and is utilized in glioblastoma research [1].
T78896	SHP2-IN-22
	SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the ...
T72836	SHP2/CDK4-IN-1
	SHP2/CDK4-IN-1 (compound 10) is a dual inhibitor targeting SHP2 and CDK4, exhibiting oral activity and high potency with IC50 values of 4.3 nM for SHP2 and 18.2 nM for CDK4. It effectively induces G0/G1 arrest, inhibitin...