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Search Results for " rsl3 "

10

Compounds

Cat No. Product Name Synonyms Targets
T3646 RSL3 RSL3 1S,1S,3R-RSL3 Ferroptosis , GPX , Glutathione Peroxidase
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.
T41203 1R,3R-RSL3 1R,3R-RSL3
1R,3R-RSL3 is a negative control for1S, 3R-RSL3.
T11631 IFSP1 Ferroptosis
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...
T2376 Liproxstatin-1 Ferroptosis
Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g., Erastin, RSL3).
T79294 NC-R17 Glutathione Peroxidase
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-targeted proteolysis targeting chimeras (PROTACs) [1].
T82408 Ferroptosis-IN-3 Ferroptosis
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS...
T37487 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE b...
T83780 GPX4 24 Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e...
T36516 RC574 RC574
RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons...
T36515 RC363
RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a...
TargetMol