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Liproxstatin-1

Catalog No. T2376   CAS 950455-15-9

Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g., Erastin, RSL3).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Liproxstatin-1 Chemical Structure
Liproxstatin-1, CAS 950455-15-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 48.00
5 mg In stock $ 81.00
10 mg In stock $ 139.00
25 mg In stock $ 313.00
50 mg In stock $ 500.00
100 mg In stock $ 549.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Purity: 99.44%
Purity: 98.07%
Purity: 98%
Purity: 97.61%
Purity: 97.53%
Purity: 97.11%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g., Erastin, RSL3).
Targets&IC50 ferroptosis:22 nM
In vitro METHODS: Mouse fibroblasts L929 were treated with Liproxstatin-1 (0-250 nM) for 24 h. Cell viability was measured using AquaBluer.
RESULTS: Liproxstatin-1 protected against FINs such as BSO (10 μM), erastin (1 μM), and RSL3 (0.5 μM) in a dose-dependent manner, while it did not rescue staurosporine (0.2 μM) or H2O2 (200 μM)-induced cell death. [1]
METHODS: Oligodendrocytes OLN93 were treated with Liproxstatin-1 (1 μM) and RSL-3 (7.89 μM) for 24 h, and GSH levels were measured by micro reduced GSH assay kit.
RESULTS: Liproxstatin-1 treatment increased GSH levels compared to the RSL-3 group. [2]
In vivo METHODS: To test the potential to prevent animal-induced Gpx4 destruction in vivo, Liproxstatin-1 (10 mg/kg) was administered intraperitoneally to TAM-treated CreERT2;Gpx4fl/fl mice once daily for two weeks.
RESULTS: Liproxstatin-1 significantly prolonged survival. the number of TUNEL+ cells in the Liproxstatin-1 group was significantly reduced, and the table Liproxstatin-1 delayed the desmoplasia of renal tubular cells. [1]
METHODS: To investigate the role of iron death in inflammation-associated cognitive deficits, Liproxstatin-1 (10 mg/kg) was administered intraperitoneally to C57BL/6 mice once daily for five days followed by LPS administration.
RESULTS: Liproxstatin-1 ameliorated memory deficits in a mouse model of LPS-induced cognitive impairment.The protective effects of Liproxstatin-1 were associated with attenuation of iron deposition and modulation of the iron-death-associated protein families, TF, xCT, Fth, Gpx4 and FtMt. [3]
Cell Research Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH). (Only for Reference)
Molecular Weight 340.85
Formula C19H21ClN4
CAS No. 950455-15-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: soluble

H2O: Insoluble

DMSO: 60 mg/ml (176.03 mM)

TargetMolReferences and Literature

1. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. 2. Fan BY, et al. Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4. Neural Regen Res. 2021 Mar;16(3):561-566. 3. Li Y, et al. The Ferroptosis Inhibitor Liproxstatin-1 Ameliorates LPS-Induced Cognitive Impairment in Mice. Nutrients. 2022 Nov 1;14(21):4599.

TargetMolCitations

1. Hu G, Cui Z, Chen X, et al.Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.Advanced Science.2023: 2206439. 2. Miao Q, Deng W, Lyu W, et al.Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRASG13D colorectal cancer.Free Radical Biology and Medicine.2023 3. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. 4. Chen J, Chen Z, Yu D, et al.Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway.Cellular and Molecular Neurobiology.2023: 1-24. 5. Dai B, Su Q, Liu X, et al.2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis.Biochemical and Biophysical Research Communications.2023 6. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 7. Zhou Y, Wu H, Wang F, et al. GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma. Frontiers in oncology. 2021, 11: 802124-802124. 8. Huang H, Chen Y, Yin N, et al. Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. Molecular Pharmaceutics. 2022 9. Qu W, Cheng Y, Peng W, et al. Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation. Molecular Neurobiology. 2022: 1-16. 10. Luo Y, Gao X, Zou L, et al. Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative Medicine and Cellular Longevity. 2021
11. Ning X, Qi H, Yuan Y, et al. Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc− to deplete GSH. European Journal of Pharmacology. 2022: 175304. 12. Wu M, Zhang X, Zhang W, et al. Cancer Stem Cell Regulated Phenotypic Plasticity Protects Metastasized Cancer Cells from Ferroptosis. Nature Communications. 2022, 13(1): 1-16. 13. Huang C Y, Chen L J, Chen G, et al. SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2022, 23(19): 11092. 14. Cheng Y, Qu W, Li J, et al. Ferristatin II, an Iron Uptake Inhibitor, Exerts Neuroprotection against Traumatic Brain Injury via Suppressing Ferroptosis. ACS Chemical Neuroscience. 2022 15. Yu F, Zhang Q, Liu H, et al. Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. Cell Discovery. 2022, 8(1): 1-17 16. Rui T, Wang H, Li Q, et al. Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis. Journal of Pineal Research. 2020: e12704. 17. Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18. Biochemical and Biophysical Research Communications. 2021, 561: 33-39. 18. Li H, Yu K, Hu H, et al.METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer.Redox Biology.2024: 103087.
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Keywords

Liproxstatin-1 950455-15-9 Apoptosis Ferroptosis Liproxstatin1 inhibit Inhibitor Liproxstatin 1 inhibitor

 

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