prmt4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T68378	PRMT4-IN-1		Histone Methyltransferase
	PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].		Histone Methyltransferase
T81399	PRMT4-IN-2
	PRMT4-IN-2 (compound 55) acts as a pan-inhibitor across various protein arginine methyltransferase (PRMT) isoforms, exhibiting inhibitory potencies with IC50 values of 92 nM for PRMT4, 436 nM for PRMT6, 460 nM for PRMT1,...
T79355	PRMT4-IN-3		Histone Methyltransferase
	PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37 nM, and displays weaker inhibition toward PRMT6, with an IC50...		Histone Methyltransferase
T28996	TP-064	TP 064	Histone Methyltransferase
	TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epig...		Histone Methyltransferase
T4378	MS049		Histone Methyltransferase
	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.		Histone Methyltransferase
T6900	MS023		Histone Methyltransferase
	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.		Histone Methyltransferase
T4393	MS049 2HCl (1502816-23-0(free base))		Histone Methyltransferase
	MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and...		Histone Methyltransferase
T11500L	GSK3368715 dihydrochloride	EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4...		Histone Methyltransferase
T61338	MS023 dihydrochloride	MS023 2HCl	Histone Methyltransferase
	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT...		Histone Methyltransferase
T10850	CMP-5		Others
	CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During hist...		Others
T27133	DCLX069	DCLX 069,DCLX-069	Histone Methyltransferase
	DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid le...		Histone Methyltransferase
T11500	GSK3368715	EPZ019997	Histone Methyltransferase
	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRM...		Histone Methyltransferase
T77787	MS023 trihydrochloride	MS023 3HCl	Histone Methyltransferase
	MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer r...		Histone Methyltransferase
T11338	Furamidine	DB75,NSC 305831	Others
	Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...		Others
T27395	Furamidine dihydrochloride	DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
	Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site ...