pde4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39210	PDE4-IN-4	PDE4-IN-4
	PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of pulmonary diseases.
T40356	PDE4-IN-3	PDE4-IN-3
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T10028	PDE4 inhibitor intermediate 1		Others
	PDE4 inhibitor intermediate 1 is a PDE4 inhibitor synthesis intermediate.		Others
T60934	PDE4-IN-9
	PDE4-IN-9 (Compound 5j) is a potent PDE4 inhibitor. In vitro enzyme assay, the IC 50 value of PDE4-IN-9 against PDE4 is 1.4 μM which is lower than 2.0 μM of parent rolipram. PDE4-IN-9 also shows good in vivo activity in ...
T60346	PDE4-IN-10
	PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1].
T61295	PDE4-IN-5
	PDE4-IN-5 (compound 33a) is a highly potent and selective inhibitor of the enzyme PDE4, with an IC50 value of 3.1 nM. It exhibits excellent skin permeability and its binding mechanism has been extensively characterized. ...
T62969	PDE4-IN-6
	PDE4-IN-6 is a safe, potent and moderately selective inhibitor of PDE4, acting on PDE4B (IC50: 0.125 μM) and PDE4D (IC50: 0.43 μM). PDE4-IN-6 is able to down-regulate TNF-α and IL-6 expression levels, exhibits anti-infla...
T79618	M3/PDE4 modulator-1
	M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor. When administered intravenously at concentrations ranging from 10 to 1000 nM/kg, this co...
T79538	PDE4-IN-13
	PDE4-IN-13 is a phosphodiesterase 4 (PDE4) inhibitor exhibiting anti-inflammatory and antioxidant activities, with an half maximal inhibitory concentration (IC50) value of 1.56 μM. It is used in the research of chronic o...
T63912	PDE4-IN-12
	PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).
T60920	PDE4-IN-8
	PDE4-IN-8 (Example 5) is a potent Phosphodiesterase 4 (PDE4) inhibitor. The IC50 value of PDE4-IN-8 for PDE4B2 is 0.93 nM. However, PDE4-IN-8 has little effect on IL13, IL4, and IFNy with IC50 values of 4.04 nM, 36.33 nM...
T79624	PDE4-IN-14
	PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including inflammatory and immune disorders, cancer, and metabolic diseases [...
T61208	PDE4-IN-11
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory air...
T61620	AChE/PDE4-IN-1
	AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in ...
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE