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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16380 | OGT 2115 | Others | |
OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM). | |||
T9711 | OGT-IN-2 | Others | |
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1]. | |||
T12039 | Miglustat | N-Butyldeoxynojirimycin,OGT918,NB-DNJ | Others |
Miglustat (NB-DNJ) is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). | |||
T40542 | Sinbaglustat | ACT-519276,Sinbaglustat,OGT2378 | Transferase |
Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain... | |||
TQ0155 | Miglustat hydrochloride | NB-DNJ hydrochloride,N-Butyldeoxynojirimycin hydrochloride,OGT918 hydrochloride | Transferase |
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease. | |||
T16409 | OSMI-1 | Others , Acyltransferase | |
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. | |||
T12328 | OSMI-4 | Others | |
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells), which can be used to study OGT inhibition in different human cell lines. | |||
T12327 | OSMI-3 | Others | |
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease. | |||
T19596 | UDP-GlcNAc Disodium Salt | Uridine 5′-diphospho-N-acetylglucosamine,UDP-α-D-N-Acetylglucosamine Disodium Salt | Others |
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). | |||
T71958 | BZX2 | ||
BZX2 is a novel inhibitor of O-GlcNAc transferase (OGT) activity. | |||
T12326 | OSMI-2 | Others | |
OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT). | |||
T69343 | BZX1 | ||
BZX1 is a novel inhibitor of O-GlcNAc transferase (OGT) activity. | |||
T63871 | PG 34 | ||
PG 34 is a structural analogue of OSMI-1 and a weak inhibitor of O-GlcNAc translocase (OGT) with an IC50 value of 68 μM. | |||
T63988 | (Rac)-OSMI-1 | ||
(Rac)-OSMI-1 is a racemate of OSMI-1. OSMI-1 is an inhibitor of O-GlcNAc transferase (OGT) (IC50: 2.7 μM). OSMI-1 inhibits protein O-linked N-acetylglucosaminoglycans (O-GlcNAcylation) in mammalian cell lines and does no... |