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Miglustat hydrochloride

Catalog No. TQ0155 CAS 210110-90-0

Synonyms: NB-DNJ hydrochloride, OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

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Miglustat hydrochloride, CAS 210110-90-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 287.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 723.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

In vivo

Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food[1].

Synonyms	NB-DNJ hydrochloride, OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride
Molecular Weight	255.74
Formula	C10H22ClNO4
CAS No.	210110-90-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 34 mg/mL (132.95 mM)

DMSO: 60 mg/mL (234.61 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. van Giersbergen, P.L. and J. Dingemanse, Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. J Clin Pharmacol, 2007. 47(10): p. 1277-82. 2. Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max FDA-Approved Drug Library Approved Drug Library Clinical Compound Library Orally Active Compound Library Inhibitor Library Metabolism Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Drug Repurposing Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Miglustat hydrochloride 210110-90-0 Metabolism Transferase NB-DNJ hydrochloride N-Butyldeoxynojirimycin OGT-918 type I gaucher disease Miglustat oral Glucosylceramide Synthase (GCS) OGT918 OGT918 hydrochloride ceramide glucosyltransferase NB-DNJ Inhibitor inhibit OGT 918 N-Butyldeoxynojirimycin hydrochloride inhibitor

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