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Miglustat hydrochloride

Name: Miglustat hydrochloride
Brand: TargetMol
SKU: TQ0155
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0155Cas No. 210110-90-0

Alias OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochloride

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

Miglustat hydrochloride

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Purity: 99.85%

Catalog No. TQ0155Alias OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochlorideCas No. 210110-90-0

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$139	In Stock
25 mg	$272	In Stock
50 mg	$428	In Stock
100 mg	$619	In Stock
200 mg	$877	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Purity:99.85%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.
In vivo	Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food[1].
Synonyms	OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochloride

Chemical Properties

Molecular Weight	255.74
Formula	C₁₀H₂₂ClNO₄
Cas No.	210110-90-0
Smiles	Cl.CCCCN1CC(O)C(O)C(O)C1CO
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 34 mg/mL (132.95 mM), Sonication is recommended.

DMSO: 60 mg/mL (234.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9102 mL	19.5511 mL	39.1022 mL	195.5111 mL
5 mM	0.7820 mL	3.9102 mL	7.8204 mL	39.1022 mL
10 mM	0.3910 mL	1.9551 mL	3.9102 mL	19.5511 mL
20 mM	0.1955 mL	0.9776 mL	1.9551 mL	9.7756 mL
50 mM	0.0782 mL	0.3910 mL	0.7820 mL	3.9102 mL
100 mM	0.0391 mL	0.1955 mL	0.3910 mL	1.9551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc