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Search Results for " oat3 "

10

Compounds

Cat No. Product Name Synonyms Targets
T6875 Lesinurad RDEA594 OAT
Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with seru...
T6098 Cabotegravir GSK744,GSK-1265744,S/GSK1265744 HIV Protease
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T35721 4’-hydroxy Trazodone
4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., T...
T69889 JBP485
JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.
T27275 Epaminurad
Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad inhibits OAT1 and OAT3 (organic anion transporter) quite modestly. Epaminurad is a u...
T81629 OAT1/3-IN-2
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3 that demonstrates potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for...
T81630 OAT1/3-IN-1
OAT1/3-IN-1 (compound 7), a dual inhibitor of OAT1 and OAT3, demonstrates the ability to mitigate the toxicity of Cys-Hg in HEK-OAT1 cells at a concentration of 10 μM and offers potential kidney protection. This compound...
T74729 18β-Glycyrrhetyl-3-O-sulfate
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) with an IC 50 va...
T70313 Indoxyl Sulfate-d5 potassium salt
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of in...
T21301 Lesinurad sodium Lesinurad,RDEA 594,RDEA-594,RDEA594
UNC569, the first small-molecule MER inhibitor, inhibits Mer activation and downstream signaling through ERK1/2 and AKTwith. UNC569 shows efficacy against acute lymphoblastic leukemia in vitro and in vivo.
TargetMol