Powder: -20°C for 3 years | In solvent: -80°C for 1 year
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) with an IC 50 value of 0.10 µM in rat kidney microsome assays. This compound acts as a substrate for organic anion transporters (OAT) 1 and OAT3. It exhibits anti-inflammatory properties and holds potential for research into pseudohyperaldosteronism [1] [2].
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Description | 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) with an IC 50 value of 0.10 µM in rat kidney microsome assays. This compound acts as a substrate for organic anion transporters (OAT) 1 and OAT3. It exhibits anti-inflammatory properties and holds potential for research into pseudohyperaldosteronism [1] [2]. |
Molecular Weight | 550.75 |
Formula | C30H46O7S |
CAS No. | 10251-38-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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18β-Glycyrrhetyl-3-O-sulfate 10251-38-4 inhibitor inhibit