Shopping Cart

Your shopping cart is currently empty

Lesinurad sodium

Name: Lesinurad sodium
Brand: TargetMol
SKU: T21301
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T21301Cas No. 1151516-14-1

Alias RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodium

Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.

Lesinurad sodium

Copy Product Info

😃Good

Purity: 99.97%

Catalog No. T21301Alias RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodiumCas No. 1151516-14-1

Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	-	In Stock
5 mg	$47	-	In Stock
1 mL x 10 mM (in DMSO)	$53	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.
Targets&IC50	CYP2C9:14.4 μM, OAT3:2 µM (Km), CYP2C8:16.2 μM, OAT1:0.85 µM (Km)
In vitro	Lesinurad sodium is a novel selective uric acid reabsorption inhibitor (SURI). Lesinurad was found to be a substrate for the renal transporter proteins organic anion transporter protein (OAT1) and OAT3 with Mie constants (Km) of 0.85 µM and 2 µM, respectively.[1] Lesinurad sodium (RDEA594) acts as an inhibitor of URAT1 and OAT and promotes uric acid excretion in the proximal renal tubules. [2] Lesinurad sodium has the potential to be a uric acid-lowering drug by inhibiting uric acid reabsorption and has demonstrated excellent P450 metabolic properties, with IC50s of 14.4 μM for CYP2C9 and 16.2 μM for CYP2C8 and IC50s of more than 100 µM for CYP1A2, CYP2C19, and CYP2D6.[3]
In vivo	Lesinurad sodium demonstrated superior pharmacokinetic properties compared to its predecessor, RDEA806, with a 100 mg dose of Lesinurad sodium producing pharmacologic effects equivalent to a single dose of 300 mg to 800 mg of RDEA806.[3] The pharmacokinetics of Lesinurad sodium were similar to those of RDEA806, which was administered as a single dose of 100 mg. [3]
Synonyms	RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodium

Chemical Properties

Molecular Weight	426.26
Formula	C₁₇H₁₃BrN₃NaO₂S
Cas No.	1151516-14-1
Smiles	O=C(CSC1=NN=C(N1C2=C3C=CC=CC3=C(C4CC4)C=C2)Br)[O-].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (187.68 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3460 mL	11.7299 mL	23.4599 mL	117.2993 mL
5 mM	0.4692 mL	2.3460 mL	4.6920 mL	23.4599 mL
10 mM	0.2346 mL	1.1730 mL	2.3460 mL	11.7299 mL
20 mM	0.1173 mL	0.5865 mL	1.1730 mL	5.8650 mL
50 mM	0.0469 mL	0.2346 mL	0.4692 mL	2.3460 mL
100 mM	0.0235 mL	0.1173 mL	0.2346 mL	1.1730 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc