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Search Result

Search Results for " ns5 "

Targets

Potassium Channel

14

Compounds

1

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T16348 NS5806 NS-5806 Potassium Channel
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
T73223 NS5A-IN-3 HCV Protease
NS5A-IN-3 (Compound 15) serves as a potent NS5A inhibitor, displaying exceptionally high efficacy against HCV genotype 1b, enhanced activity towards genotype 3a (GT 3a), and substantial metabolic stability. It also demon...
T73834 NS5A-IN-2 HCV Protease
NS5A-IN-2 (Compound 33) serves as a potent NS5A inhibitor exhibiting exceptional efficacy against HCV genotype 1b, enhanced activity against genotype 3a (GT 3a), and notable metabolic stability [1].
T74403 NS5A-IN-1
NS5A-IN-1 is a proagent of the HCV NS5A inhibitor Pibrentasvir (ABT-530).
T28198 NS5818 NS-5818,NS 5818
NS5818 inhibits ClC.
T74495 NS5A-IN-4
NS5A-IN-4 (Compound 1.12) is a pan-genotypic, orally active inhibitor of the hepatitis C virus (HCV) NS5A, exhibiting IC50 values of 1.2, 2296, 4.6, 362, 10.3, and 693 pM against genotypes gT1b, gT1a, gT2a, gT3a, gT4a, a...
T72051 LabMol-319 Virus Protease
LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.
T64123 ZIKV-IN-5
ZIKV-IN-5 is an acid-stable, low cytotoxic anti-ZIKV agent with an EC50 value of 0.71 μM. ZIKV-IN-5 showed effective inhibition of ZIKV NS5 MTase activity.
T73156 LabMol-301
LabMol-301, a chemical compound, effectively inhibits NS5 RdRp and NS2B-NS3pro activity with IC50 values of 0.8 μM and 7.4 μM, respectively. Additionally, it exhibits cytoprotective effects, safeguarding against Zika vir...
T71748 RK-0404678
RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T63533 ZIKV-IN-4
ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.
T64067 ZIKV-IN-2
ZIKV-IN-2 is a potent inhibitor of ZIKV NS5 methyltransferase (MTase) (IC50: 38.86 μM) and inhibits the replication and infection of ZIKV, which can be used to study Zika virus (ZIKV).
T73292 ZIKV-IN-3
ZIKV-IN-3, a derivative of andrographolide, serves as a potent inhibitor of the Zika virus (ZIKV) NS5 methyl transferase (MTase), showcasing an IC50 of 18.34 μM. It effectively curtails ZIKV replication and infection, ma...
T80729 ZIKV-IN-6
ZIKV-IN-6 (compound 22) acts as a direct inhibitor of the Zika virus (ZIKV) by binding to its RNA-dependent RNA polymerase (RdRp) and obstructing viral RNA synthesis mediated by the ZIKV NS5 protein. This compound also d...
Cat No. Product Name Synonyms Targets
TN2222 Sotetsuflavone Others
Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).

Natural Products

Sotetsuflavone
TN2222
Synonym:
Target: Others

Recombinant Proteins

Species：
DENV (1)
Human (1)
ZIKV (1)
Expression System：
Baculovirus Insect Cells (2)
E. coli (1)
Tag：
C-His (1)
His, GST (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPY-05024 Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His) ZIKV Baculovirus Insect Cells
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase.
TMPY-05095 RAF1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPY-00279 Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His) DENV E. coli
Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35.5 kDa and the ac...
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