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Sotetsuflavone

Catalog No. TN2222 CAS 2608-21-1

Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).

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Sotetsuflavone, CAS 2608-21-1

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 550.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 850.00

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Description	Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).
In vitro	Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.
Source	Natural Products > Selaginellaceae > Selaginella

Molecular Weight	552.48
Formula	C31H20O10
CAS No.	2608-21-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.Planta Med. 2013 Sep;79(14):1313-8.

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Sotetsuflavone 2608-21-1 Others inhibitor inhibit

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