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Search Results for " nci-h358 "

5

Compounds

Cat No. Product Name Synonyms Targets
T1933 NVP 231 Apoptosis , ERK
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
T69529 BI-0474 Ras
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G...
T79108 SHP2-IN-14
SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2, displaying strong anti-tumor activity with an IC50 of 7 nM. It inhibits tumor progression in NCI-H358 tumor-bearing mice and demonstrates ...
T63823 K20
K20 is a potent and selective inhibitor of KRas G12C (IC50: 1.16 nM). In H358 cells, K20 has an anticancer effect with an IC50 value of 0.78 μM. K20 inhibits the growth of NCI-H358 tumor cells (TGI: 41%) without signific...
T83865 HP661
HP661, a selective inhibitor of mitochondrial complex I (NADH dehydrogenase), impedes complex I activity by 77.6% at 1 µM, demonstrating lesser inhibition towards complex III (28.1%) and no inhibitory effects on complexe...
TargetMol