n-ras — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2678	LB42708		Transferase
	LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).		Transferase
T6302	Lonafarnib	Sarasar,Sch66336	Raf , Transferase , Autophagy , Ras
	Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).		Raf , Transferase , Autophagy , Ras
T9935	UCM-1336	3,3′-(Octylimino)bis[N-phenylpropanamide]	Others
	UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.		Others
T9533	BC-LI-0186	4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide	Others
	BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protei...		Others
T18847	THP-PEG4-Pyrrolidine(N-Me)-CH2OH		Others
	THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, facilitates the synthesis of PROTAC K-Ras Degrader-1[1].		Others
T82086	ICMT-IN-7
	ICMT-IN-7 (compound 74), with an IC50 value of 0.015 µM, functions as an ICMT inhibitor, promotes cytoplasmic accumulation of ICMT in HCT-116 cells in a dose-dependent manner and suppresses the proliferation of various c...
T72707	(Rac)-Lonafarnib	Sch66336 racemate
	(Rac)-Lonafarnib (Sch66336 racemate) is the racemic form of the potent, orally active farnesyl transferase (FTase) inhibitor, Lonafarnib. It effectively inhibits H-ras, K-ras, and N-ras with IC50 values of 1.9 nM, 5.2 nM...
T18846	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH		Others
	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1].		Others
T82136	ICMT-IN-1
	ICMT-IN-1 (compound 75) is a potent ICMT inhibitor with an IC50 value of 0.0013 μM. This compound promotes dose-dependent cytoplasmic accumulation of ICMT in HCT-116 cells and effectively inhibits the proliferation of va...
T73481	ABD957
	ABD957, a potent and selective covalent inhibitor of the ABHD17 depalmitoylase family, exhibits an IC 50 value of 0.21 µM against ABHD17B. This compound effectively inhibits N-Ras signaling and suppresses the growth of N...

Compounds

LB42708

T2678

Synonym: Sarasar,Sch66336

Target: Raf, Transferase, Autophagy, Ras

UCM-1336

T9935

Synonym: 3,3′-(Octylimino)bis[N-phenylpropanamide]

Target: Others

BC-LI-0186

T9533

Synonym: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide

Target: Others

THP-PEG4-Pyrrolidine(N-Me)-CH2OH

Synonym: Sch66336 racemate

Target:

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03487	NRAS Protein, Human, Recombinant (His)	Human	E. coli
	NRAS was discovered by researchers at the Institute of Cancer Research, funded by the Cancer Research Campaign (now Cancer Research UK). NRAS gene is a member of the Ras gene family. It is mapped on chromosome 1, and it ...
TMPH-01756	Neurofibromin/NF1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Neurofibromin/NF1 Protein, Human, Recombinant (His & Myc) is expressed in E....
TMPH-03359	LOX Protein, Rat, Recombinant (His)	Rat	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPH-01969	LOX Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPH-03445	GSP1 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	P. pastoris (Yeast)
	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP i...
TMPH-01422	GNAS Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting...