mpro — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-i...
T38175	MPro N3
	Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibit...
T38174	Mpro inhibitor N3 hemihydrate
	Mpro inhibitor N3 hemihydrate is a potent antagonist of the SARS-CoV-2 main protease (Mpro), demonstrating an EC50 of 16.77 μM against SARS-CoV-2. It exhibits specific inhibition of Mpro in a range of coronaviruses, incl...
T63098	SARS-CoV-2 Mpro-IN-2
	SARS-CoV-2 MPro-IN-2 is a selective, low cytotoxic, non-covalent Mpro inhibitor with an IC50 value of 0.40 μM. SARS-CoV-2 Mpro-IN-2 showed good anti-SARS-CoV-2 effect with EC50 value of 1.1 μM. SARS-CoV-2 Mpro-IN-2 can b...
T37174	SARS-CoV MPro-IN-1
	MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-in...
T69545	Mpro 61
	Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease.
T62991	Mpro/PLpro-IN-1
	Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease.Mpro/PLpro-IN-1 is also a potent inhibitor of Mpro/PLpro, with micromolar inhibition of M pro (IC50:1.72 μM) and submicromolar inhibition of...
T72581	SARS-CoV MPro-IN-2
	SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus's replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing ...
T60686	SARS-CoV-2 Mpro-IN-1
	SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible SARS-CoV-2 main protease (Mpro) inhibitor (IC 50 = 116 nM) [1].
T72451	SARS-CoV-2 Mpro-IN-6
	SARS-CoV-2 Mpro-IN-6 is a selective, covalent, and irreversible inhibitor of SARS-CoV-2 main protease (Mpro), exhibiting an inhibition concentration (IC50) of 0.18 μM. It does not inhibit human cathepsins B, F, K, and L ...
T72447	SARS-CoV-2 Mpro-IN-5
	SARS-CoV-2 Mpro-IN-5 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL) with IC50 values of 1800 nM and 145 nM, respectively. This compound demonstrates antiviral activity by inhibiting SARS-CoV-2...
T79515	SARS-CoV-2 Mpro-IN-10		SARS-CoV
	SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in research focused on the SARS-CoV-2 virus [1].		SARS-CoV
T79455	SARS-CoV-2 Mpro-IN-9		SARS-CoV
	SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma...		SARS-CoV
T81210	SARS-CoV-2 Mpro-IN-12		SARS-CoV
	SARS-CoV-2 Mpro-IN-12 (compound D026) serves as an inhibitor of the main protease (Mpro) of SARS-CoV-2, exhibiting antiviral properties [1].		SARS-CoV
T79278	SARS-CoV-2 Mpro-IN-7		SARS-CoV
	SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50) of 10 μM [1].		SARS-CoV
T79279	SARS-CoV-2 Mpro-IN-8		SARS-CoV
	SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].		SARS-CoV
T72446	SARS-CoV-2 Mpro-IN-4
	SARS-CoV-2 Mpro-IN-4 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL), exhibiting inhibition concentrations (IC50) of 900 nM and 60 nM, respectively. It demonstrates antiviral activity by effect...
T72231	SARS-CoV-2/MERS Mpro-IN-2
	SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 µM, respectively.
T72230	SARS-CoV-2/MERS Mpro-IN-1
	SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 µM, respectively.
T1307	Carmofur	HCFU	Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis
	Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.