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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6588 | Mitoxantrone | mitozantrone | Topoisomerase , PKC |
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... | |||
T0158 | Mitoxantrone dihydrochloride | Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride | Topoisomerase , PKC |
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. | |||
T63997 | Mitoxantrone diacetate | ||
Mitoxantrone diacetate is a potent inhibitor of topoisomerase II. Mitoxantrone diacetate also inhibits protein kinase C (PKC) (IC50: 8.5 μM). Mitoxantrone diacetate exhibits antitumour effects and also has an antiorthopo... | |||
TN3150 | 6,8-Diprenylnaringenin | Senegalensin,Lonchocarpol A | BCRP , ABC |
6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity. | |||
T61351 | Pixantrone hydrochloride | ||
Pixantrone (BBR 2778 (free base)) hydrochloride is a mitoxantrone analog compound that acts as a topoisomerase II inhibitor and DNA intercalator. It displays anti-tumor activity [1] [2]. | |||
T83892 | 33-BCRP Inhibitor | 33-Breast Cancer Resistance Protein Inhibitor | |
33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantro... | |||
T74737 | Mono-Pal-MTO | ||
Mono-Pal-MTO, a palm oil-derived lipid formed by integrating the anticancer agent mitoxantrone (MTO) with palmitoleic acid, exhibits enhanced anticancer activity and efficient siRNA cell delivery when its nanoparticles a... | |||
T74738 | Di-Pal-MTO | ||
Di-Pal-MTO, a lipid derivative synthesized from palm oil by integrating the anticancer agent mitoxantrone (MTO) with palmitoleic acid, exhibits enhanced anticancer activity and efficient siRNA cell delivery when nanopart... | |||
T70222 | Ethonafide | ||
Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone... | |||
T62582 | WEHI-150 | ||
WEHI-150 is an analog of mitoxantrone, a DNA interstrand cross-linker (t1/2=12.5 h). WEHI-150 is capable of forming covalent adducts on CpG sequences, with a particular preference for methylated CpG sites. Formaldehyde-a... |