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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11967 | Mcl-1 antagonist 1 | Others | |
Mcl-1 antagonist 1 is a Mcl-1 protein antagonist. | |||
T40230 | Mcl-1 inhibitor 6 | ||
Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compou... | |||
T12041 | MIM1 | Inhibitor of Mcl-1 | BCL |
MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor. | |||
TP1889 | MCL0020 | MCL 0020 | Melanocortin Receptor |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e... | |||
T11972 | Mcl-1 inhibitor 3 | BCL | |
Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an... | |||
T11968 | MCL-1/BCL-2-IN-1 | BCL | |
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1]. | |||
T11971 | MCL-1/BCL-2-IN-4 | Others | |
MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor. | |||
T11969 | MCL-1/BCL-2-IN-2 | Others | |
MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor. | |||
T11970 | MCL-1/BCL-2-IN-3 | Others | |
MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely. | |||
T27997 | MDK-3345 | MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11 | |
MDK-3345 is a reversible covalent inhibitor for Mcl-1. | |||
T10096L | Voruciclib | CDK | |
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ... | |||
T18487 | NH2-C6-NH-Boc | Others , PROTAC Linker | |
NH2-C6-NH-Boc is a PROTAC linker. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC. | |||
T27996 | MDK-3298 | Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5 | |
MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI). | |||
T72610 | Mcl-1 inhibitor 9 | ||
Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM. | |||
T79036 | Mcl-1 inhibitor 13 | ||
Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1]. | |||
T75143 | Mcl-1 inhibitor 12 | ||
Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1]. | |||
T79215 | Mcl-1 inhibitor 14 | ||
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potential for use in anticancer research [1]. | |||
T79216 | Mcl-1 inhibitor 15 | ||
Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1]. | |||
T79242 | Mcl-1 inhibitor 16 | ||
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells. This compound exhibits antitumor activity and may be utilized as a ... | |||
T68398 | MI-223 | ||
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress. |