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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21351 | Maytansine | NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine | Microtubule Associated , Antibiotic |
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. | |||
T80884 | Val-Cit-amide-Ph-Maytansine | ||
Val-Cit-PAB-MMAE is a molecular entity designed to function as an antibody-drug conjugate (ADC) or as a component of bispecific antigen-binding molecules, specifically targeting the hepatocyte growth factor receptor know... | |||
T80885 | Val-Cit-amide-Cbz-N(Me)-Maytansine | ||
Val-Cit-amide-Cbz-N(Me)-Maytansine is a molecule that functions both as an antibody and a bispecific antigen-binding entity, targeting the hepatocyte growth factor receptor c-Met (MET), and is used in the formulation of ... | |||
T1992 | Mertansine | DM1,Maytansinoid DM1 | Microtubule Associated |
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4... | |||
T21408 | DM1-SMe | DM1-SSMe | Microtubule Associated |
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ... | |||
T18730 | Sulfo-SPDB-DM4 | Others | |
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker. | |||
T11057 | DM3-SMe | Others | |
DM3-SMe is a maytansine derivative and tubulin inhibitor. It is a cytotoxic part of antibody-drug conjugates (ADCs) and can bind to antibodies via disulfide bonds or stable thioether bonds. DM3-SMe has high cytotoxic act... | |||
T13766 | Maytansinoid DM4 | Others | |
Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications. | |||
T12805 | S-methyl DM1 | Microtubule Associated | |
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization. | |||
T18701 | SPDB-DM4 | Others | |
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si... | |||
T36647 | Trastuzumab emtansine | Others | |
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory deriv... | |||
T11058 | DM3 | Maytansinoid DM3 | Others |
DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates (ADCs) . | |||
T17832 | DM1-PEG4-DBCO | Others | |
DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to m... | |||
T76939 | Cantuzumab mertansine | ||
Cantuzumab mertansine (SB-408075; huC242-DM1), an antibody-drug conjugate (ADC), comprises the potent maytansine derivative (DM1) linked to the humanized monoclonal antibody (huC242) targeting CanAg. Demonstrating cytoto... |