mtap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9575	MRTX9768		Histone Methyltransferase
	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.		Histone Methyltransferase
T8227	5'-Methylthioadenosine	Methylthioadenosine,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine	Endogenous Metabolite
	5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.		Endogenous Metabolite
T14141	AGI-24512		Others , Methionine Adenosyltransferase (MAT)
	AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro.		Others , Methionine Adenosyltransferase (MAT)
TQ0008	MT-DADMe-ImmA	Methylthio-DADMe-Immucillin A,MTDIA	Others
	MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).		Others
T73494	TNG908
	TNG908, a MTAP-cooperative PRMT5 inhibitor capable of penetrating the blood-brain barrier, demonstrates 15-fold greater selectivity for MTAP cell lines over MTAP WT (wild type) cell lines. Its application is primarily in...
T40254	MRTX-1719		Histone Methyltransferase
	MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.		Histone Methyltransferase
T31672	Erythrofuranosyladenine	9-β-D-Erythrofuranosyladenine,ETA
	Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute l...
T33517	MTDIA HCl	MTDIA,Methylthio-DADMe-Immucillin A,MT-DADMe-ImmA,MT-DADMe-ImmA HCl
	MTDIA (MT-DADMe-ImmA and methylthio-DADMe-Immucillin A) is an MTAP inhibitor.
T15691	L-Alanosine	NSC-153353	Others
	L-Alanosine inhibits adenylosuccinate synthetase. L-Alanosine is an antibiotic from Streptomyces alanosinicus with antineoplastic activity. L-Alanosine blocks the common de novo purine biosynthesis pathway and, thereby, ...		Others
T79873	TNG-462		Histone Methyltransferase
	TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1].		Histone Methyltransferase
T36630	MRTX9768 hydrochloride
	MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT...
T10259	AGI-25696		Others , Methionine Adenosyltransferase (MAT)
	AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies about the treatment of cancer.		Others , Methionine Adenosyltransferase (MAT)
T69811	AGI25696
	AGI-25696 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-25696 showed in vivo activity in MTAP null tumors. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many ve...
T79350	MAT2A-IN-12		Methionine Adenosyltransferase (MAT)
	MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assays utilizing the MTAP -/- cell line [1].		Methionine Adenosyltransferase (MAT)
T63975	MAT2A-IN-1
	MAT2A-IN-1 is a potent inhibitor of MAT2A and is capable of proliferative activity in MTAP-deficient cancer cells. MAT2A is expressed at unusually high levels in several tumour types, including gastric, colon, liver and ...
T62100	MAT2A-IN-6
	MAT2A-IN-6 is a potent inhibitor of MAT2A. MAT2A-IN-6 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-6 has shown potential research value in cancer diseases.
T61243	MAT2A-IN-5
	MAT2A-IN-5, a potent inhibitor of MAT2A, effectively targets the abnormally elevated expression of MAT2A found in various tumor types such as gastric, colon, liver, and pancreatic cancers. By reducing the proliferative a...
T63603	MAT2A-IN-3
	MAT2A-IN-3 is a potent inhibitor of MAT2A. MAT2A-IN-3 inhibits the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has shown research potential for cancer diseases.
T61672	MAT2A-IN-7
	MAT2A-IN-7, a potent inhibitor of the enzyme MAT2A, demonstrates efficacy in targeting the abnormally elevated expression of MAT2A observed in gastric, colon, liver, and pancreatic cancers. Furthermore, MAT2A-IN-7 effect...
T62984	MAT2A-IN-2
	MAT2A-IN-2 is a potent inhibitor of MAT2A. MAT2A-IN-2 has potential for cancer disease research.