Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 137.00 | |
10 mg | In stock | $ 237.00 | |
25 mg | In stock | $ 447.00 | |
50 mg | In stock | $ 659.00 | |
100 mg | In stock | $ 939.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 172.00 |
Description | MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM). |
Targets&IC50 | MTAP:90 pM (Ki, cell free) |
In vitro | Treatment of cultured cells with MTA and MT-DADMe-ImmA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. MT-DADMe-ImmA alone does not induce apoptosis in any cell line [2]. |
In vivo | MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA [2]. |
Cell Research | Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM) [2]. |
Animal Research | Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with an oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA [2]. |
Synonyms | Methylthio-DADMe-Immucillin A, MTDIA |
Molecular Weight | 293.39 |
Formula | C13H19N5OS |
CAS No. | 653592-04-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (170.42 mM)
You can also refer to dose conversion for different animals. More
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MT-DADMe-ImmA 653592-04-2 Others Methylthio-DADMe-Immucillin A MTDADMeImmA inhibit MTDIA MT DADMe ImmA Inhibitor inhibitor