mgl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3595	Resmetirom	VIA-3196,MGL3196	Thyroid hormone receptor(THR)
	Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.		Thyroid hormone receptor(THR)
T7688	4-Nonylphenylboronic acid		FAAH
	4-Nonylphenylboronic acid is a inhibitor of FAAH.		FAAH
T9970	mGluR3 modulator-1	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile	GluR
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.		GluR
T12717	Basimglurant	CTEP Derivative,RG7090	GluR
	Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).		GluR
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) can be used in antipsychotic research. mGluR2 modulator 2 is a potent, selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC 50 value of 0.13 μM [1].
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ...
T81801	mGluR5 antagonist-1
	mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p...
T38659	mGluR5 modulator 1
	mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment...
T74287	MGlc-DAG
	MGlc-DAG, a glycoglycerolipid, serves as a precursor in the synthesis of drug delivery compounds [1].
T61775	mGlu4 receptor agonist 1
	mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [...
T3591	URB602		Lipase , Antibacterial
	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.		Lipase , Antibacterial
T28165	NF-1819	NF 1819,NF1819	Lipase
	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model ...		Lipase
T5737	Euphol		Others , Lipase , Endogenous Metabolite
	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.		Others , Lipase , Endogenous Metabolite
T4S1050	Pristimerin	Celastrol methyl ester	NF-κB , Antibacterial
	1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...		NF-κB , Antibacterial
T71493	AM6580
	AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
T34521	SAR629	SAR 629,SAR-629
	SAR-629 is an MGL inhibitor or 2-AG degradation inhibitor.
T61294	Monoacylglycerol lipase inhibitor 1
	Monoacylglycerol lipase inhibitor 1, also known as compound 13 [1], is a potent inhibitor of monoacylglycerol lipase.