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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10917 | LTB4-IN-1 | Anti-inflammatory agent 2 | LTR |
LTB4-IN-1 (Anti-inflammatory agent 2) with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4). | |||
T10960L | Darbufelone mesylate | CI-1004 mesylate | Prostaglandin Receptor , LTR |
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 value of 20 μM. | |||
T38157 | Ricinelaidic Acid | ||
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu... | |||
T24970 | 1'-Ethylascorbigen | ||
1'-Ethylascorbigen releases ascorbic acid in acidic solution results in an increase in the cells' ability to produce PGE2 & LTB4. It has been shown to inhibit the growth of experimental murine tumors. | |||
T79389 | LTB4-IN-2 | FLAP | |
LTB4-IN-2 (Compound 6x) is a selective inhibitor of Leukotriene B4 (LTB4), acting by specifically targeting the 5-Lipoxygenase-activating protein (FLAP) with an inhibitory concentration (IC 50) of 1.15 μM, thus serving a... | |||
T14210 | Amelubant | BIIL 284 | LTR |
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 rece... | |||
T14205 | AM679 | Others | |
AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition ... | |||
T36052 | Lipoxin A4 methyl ester | LXA4 methyl ester | |
Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism ... | |||
T37265 | 15(R)-Lipoxin A4 | 15(R)-Lipoxin A4,AT-Lipoxin A4 | |
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspiri... | |||
T37969 | 12(S)-HpETE | ||
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the sy... | |||
T83773 | Prostaglandin E2 Inhibitor 3 | PGE2 Inhibitor 3 | |
Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... | |||
T35463 | (±)14(15)-EET | (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET | |
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i... |