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Cat No. | Product Name | Synonyms | Targets |
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T15782 | Lp-PLA2-IN-1 | Lp-PLA2 inhibitor 1,Lp-PLA2 -IN-1 | Phospholipase |
Lp-PLA2-IN-1 (Lp-PLA2 inhibitor 1) suppresses Lp-PLA2 activity processes for their preparation. Lp-PLA2-IN-1 (Lp-PLA2 inhibitor 1) also inhibits to compositions containing them and to their use in the treatment of diseas... | |||
T11874 | Lp-PLA2-IN-3 | Phospholipase | |
Lp-PLA2-IN-3 is a potent and orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor that inhibits recombinant human Lp-PLA2 with an IC50 value of 14 nM. | |||
T11873 | Lp-PLA2-IN-2 | Phospholipase | |
Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2. | |||
T79076 | Lp-PLA2-IN-16 | Phospholipase | |
Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1]. | |||
T79075 | Lp-PLA2-IN-15 | Phospholipase | |
Lp-PLA2-IN-15 (example 2) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential application in Alzheimer's disease research [1]. | |||
T79074 | Lp-PLA2-IN-14 | Phospholipase | |
Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4. This compound is applicable in research pertaining to neurodegenerative disorders, including Alzheime... | |||
T62947 | Lp-PLA2-IN-11 | ||
Lp-PLA2-IN-11 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2-IN-11 has the potential to be investigated in diseases associated with Lp-PLA2 activity (e.g. atherosclerosis, Alzheimer's... | |||
T63345 | Lp-PLA2-IN-5 | ||
Lp-PLA2-IN-5 is a potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2-IN-5 has the potential to be studied in diseases associated with Lp-PLA2 activity, such as Alzheimer's disease, atherosclerosi... | |||
T63633 | Lp-PLA2-IN-6 | ||
Lp-PLA2-IN-6 is a tetracyclic pyrimidinone compound that is a potent inhibitor of Lp-PLA2 and is able to act on rhLp-PLA2 (pIC50: 10.0). lp-PLA2-IN-6 has shown research potential in neurodegenerative diseases. | |||
T63931 | Lp-PLA2-IN-9 | ||
Lp-PLA2-IN-9 (compound 17) is a tetracyclic pyrimidinone compound, a potent inhibitor of Lp-PLA2 that acts on rhLp-PLA2 (pIC50: 10.1). lp-PLA2-IN-9 has shown research potential in neurodegenerative diseases. | |||
T79073 | Lp-PLA2-IN-13 | Phospholipase | |
Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1]. | |||
T63344 | Lp-PLA2-IN-4 | ||
Lp-PLA2-IN-4 is a potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2-IN-4 has the potential to be studied in diseases associated with Lp-PLA2 activity, such as Alzheimer's disease, atherosclerosi... | |||
T79010 | Lp-PLA2-IN-12 | Phospholipase | |
Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions... | |||
T63192 | Lp-PLA2-IN-10 | ||
Lp-PLA2-IN-10 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), formerly known as platelet-activating factor acetylhydrolase (PAF-AH). This enzyme plays a role in the hydrolysis of lipoprotein l... | |||
T16751 | Rilapladib | SB 659032 | Phospholipase |
Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating factor receptor. | |||
T6109 | Darapladib | SB-480848 | Phospholipase |
Darapladib (SB-480848)(IC50=0.25 nM) is a substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2). | |||
T31204 | Darapladib-impurity | Others | |
Darapladib-impurity is the impurity of Darapladib. Darapladib inhibits lipoprotein-associated phospholipase A2 (Lp-PLA2). | |||
T75255L | SB-435495 hydrochloride | ||
SB-435495 hydrochloride is a potent, selective, reversible, non-covalent, and orally active inhibitor of Lp-PLA2, exhibiting an IC50 of 0.06 nM [1] [3]. | |||
T75255L1 | SB-435495 ditartrate | ||
SB-435495 ditartrate is a potent, selective, reversible, non-covalent, and orally active inhibitor of Lp-PLA2, demonstrating an IC50 value of 0.06 nM [1] [3]. | |||
T75255 | SB-435495 | ||
SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM. It is effective when administered orally. | |||
T63421 | GSK2647544 | ||
GSK2647544 is an orally active selective inhibitor of Lp-PLA2, a calcium non-dependent phospholipase A2 secreted primarily by monocyte-derived macrophages that exhibits pro-inflammatory effects. |
Cat No. | Product Name | Synonyms | Targets |
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T10017 | 1-Linoleoyl Glycerol | Glycerol 1-monolinolate,Monolinolein,Glyceryl monolinoleate,1-Linoleoyl-rac-glycerol | Phospholipase |
1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots. The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A2 (... | |||
TN5288 | Ergosterol peroxide glucoside | Ergosterol peroxide 3-O-β-D-glucopyranoside | |
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits h... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01881 | Lp-PLA2/PLA2G7 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Lp-PLA2/PLA2G7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is Q13093-1. | |||
TMPY-04692 | Lp-PLA2/PLA2G7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Lp-PLA2/PLA2G7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.3 kDa and the accession number is Q60963. | |||
TMPJ-00553 | Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His) | Human | HEK293 Cells |
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive... |