Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lp-PLA2-IN-3 is a potent and orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor that inhibits recombinant human Lp-PLA2 with an IC50 value of 14 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 767.00 | |
50 mg | In stock | $ 1,070.00 | |
100 mg | In stock | $ 1,450.00 | |
500 mg | In stock | $ 2,880.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | Lp-PLA2-IN-3 is a potent and orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor that inhibits recombinant human Lp-PLA2 with an IC50 value of 14 nM. |
Targets&IC50 | Lp-PLA2:14 nM |
In vivo |
Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively.[1] Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the Cmax, AUC0-24h, t1/2, and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours, and 35.5%, respectively.[1] |
Molecular Weight | 467.85 |
Formula | C20H13ClF3N3O3S |
CAS No. | 2196245-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (534.36 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lp-PLA2-IN-3 2196245-16-4 Metabolism Phospholipase LpPLA2IN3 Lp-PLA-2-IN-3 Lp PLA2 IN 3 inhibitor inhibit