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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12504 | (+)-KCC2 blocker 1 | Potassium Channel | |
(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM). | |||
T14984 | CLP257 | Potassium Channel | |
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al... | |||
TQ0139 | VU 0240551 | N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4 | Potassium Channel , Calcium Channel , HER |
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG. | |||
T17243 | VU0463271 | N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide | Potassium Channel |
VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM ... | |||
T5444 | CLP290 | CLP-290 | Potassium Channel |
CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications. | |||
T71992 | ML-077 | ||
ML-077, also known as VU0255011, is a highly selective, potent, saline soluble, best in class" KCC2 antagonist for high fidelity in vitro studies on KCC2 function with IC(50)=537 nM. ML-077 is cell permeable and exhibit... | |||
T61725 | VU0463271 quarterhydrate | ||
VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1]. |